Treatment retention, return to use, and recovery support following COVID-19 relaxation of methadone take-home dosing in two rural opioid treatment programs: A mixed methods analysisResearch article Published on 2022-10-012022-10-05 Journal: Journal of substance abuse treatment [Category] 치료법, [키워드] Abuse Analysis association change clinically COVID-19 dose doses Effect EHR employment expected feasible FIVE Health increase in individual less Medication for opioid use disorder Methadone objective opioid Opioid treatment OTP Patient patients positive positive result Probability Program promoted public health Qualitative qualitative analysis Quantitative reaction reduced regimens Regression model Result rural service substance Support supported Travel Treatment triggers Urine [DOI] 10.1016/j.jsat.2022.108801 [Article Type] Research article
Public awareness for “classic” childhood diseases and inflammatory syndromes in children during the COVID-19 pandemicShort communication Published on 2022-09-012022-10-05 Journal: Journal of pediatric nursing [Category] 진단, 치료기술, [키워드] Better Chickenpox childhood children connection Course COVID-19 COVID-19 pandemic disease Diseases FIVE Google Google Trends implication in silico Inflammatory inflammatory disease intensity Kawasaki disease media MIS-C mumps objective pandemic pediatric PIMS PMIS Practice Public public interest remained Result scarlet fever Search engine data syndrome trend triggers was performed were used with COVID-19 [DOI] 10.1016/j.pedn.2022.06.015 [Article Type] Short communication
Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion말초 혈액 단핵 세포의 차별적인 염색질 접근성은 혈청 전환 이전의 COVID-19 질병 중증도의 기초가 됩니다Article Published on 2022-07-092022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] Accessibility anti-spike protein IgG Antiviral ATAC-seq CD14 CD14+ monocytes Cell cell differentiation cell type cell types changes in chromatin classical Course COVID-19 COVID-19 disease severity defined diagnostic disease disease course dysregulated early disease effective epigenome Evolution hosts IgG immune response immune responses individual Infection interleukin interleukin signaling IRF1 IRF7 less Mild mild SARS-CoV-2 infection Mild symptom moderate moderate disease moderate symptom Modification modifications Monocytes mononuclear cell mononuclear cells morphology motif observation occurred offer Outpatient outpatients Pathways PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells profile promise Regulation remodeling responses RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection Sequencing Seroconversion severity Signaling single-cell analyses single-cell analysis Stage Symptom symptom severity the disease transcription factor transposase Trigger triggers upregulation with COVID-19 [DOI] 10.1038/s41598-022-15668-8 PMC 바로가기 [Article Type] Article
Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathologySARS-CoV-2에 의한 Gasdermin-D 활성화는 NET을 유발하고 COVID-19 면역병리를 매개합니다Article Published on 2022-07-072022-09-11 Journal: Critical Care [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] activate Activation Analysis analyzed Blood Bronchoalveolar lavage Coagulopathy COVID-19 COVID-19 patients Critical demonstrated disulfiram enrolled expression GSDMD hospitalized patient immunopathology infect Inflammasome Inflammation inhibited Innate Innate immunity live SARS-CoV-2 lung tissue lung tissue sample moderate molecular mechanism molecular mechanisms mouse model NET NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils organ damage Organ damage. pathway Pathways performed Protein reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Severe case severe cases severe COVID-19 signaling pathway single-cell Structure the SARS-CoV-2 virus therapeutic strategy Transcriptome Treatment Trigger triggers [DOI] 10.1186/s13054-022-04062-5 PMC 바로가기 [Article Type] Article
Cytokeratin 18 cell death assays as biomarkers for quantification of apoptosis and necrosis in COVID-19: a prospective, observational studyCOVID-19에서 세포자멸사 및 괴사의 정량화를 위한 바이오마커로서의 Cytokeratin 18 세포 사멸 분석: 전향적 관찰 연구Observational Study Published on 2022-06-012022-09-11 Journal: Journal of Clinical Pathology [Category] Coronavirus, COVID19(2023년), MERS, SARS, 바이오마커, 임상, [키워드] admitted patients Adult patients Apoptosis appear assays Biomarker blood sample Blood samples Care caspase cell damage cell death clinical trials collected Control controls COVID-19 COVID-19 patient COVID-19 patients cytokeratin discharged patients elevated emergency department enrolled enzyme epithelial epithelial cell estimation hospitalisation hospitalised hospitalised COVID-19 patients ICU admission independent predictor independent predictors Intact intensive care unit mechanism multivariable logistic regression Necrosis non-ICU Patient patients patients with COVID-19 presenting quantification relative contribution relative contributions respiratory respiratory symptom respiratory symptoms risk stratification SARS-CoV-2 severe disease sick therapeutic efficacy Trigger triggers Virology Virology. [DOI] 10.1136/jclinpath-2020-207242 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 triggering autoimmune diseases자가 면역 질환을 유발하는 SARS-CoV-2Review Published on 2022-06-012022-09-11 Journal: Cytokine [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] acquired immunity Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ARDS autoantibody autoimmune antibodies Autoimmune disease Autoimmunity autoreactivity bystander caused CD4 CD8 chronic inflammation contribute coronavirus COVID-19 COVID-19 pandemic cytokine cytokine secretion Cytokine storm element elicit Evidence high mortality Hyperactivation Hyperstimulation immune response immune system Immunity immunological Immunosuppression Inflammation mechanism molecular molecular interaction molecular mimicry pandemic Patient respiratory respiratory distress Respiratory distress syndrome respiratory epithelium SARS-CoV-2 SARS-CoV-2. scarcity self-tolerance severe acute respiratory syndrome Coronavirus syndrome T cells the disease thought Trigger triggering triggers variety virus virus viruses [DOI] 10.1016/j.cyto.2022.155873 PMC 바로가기 [Article Type] Review
Miller Fisher syndrome after COVID-19 vaccination: Case report and review of literature코로나19 백신 접종 후 밀러 피셔 증후군: 증례 보고 및 문헌 검토Review Published on 2022-05-202022-09-11 Journal: Medicine [Category] 변종, [키워드] adverse effect albuminocytologic dissociation Analysis areflexia Ascending paralysis association Ataxia Blood cerebrospinal fluid Complete Complication coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccinations diagnosed Diagnosis Diplopia discharge ENhance febrile febrile illness first dose Fisher syndrome Guillain-barrè syndrome hypertensive immunoglobulins Infection intravenous latency lower limb lower limbs male management Miller Miller fisher syndrome moderate Nerve conduction ophthalmoplegia paralysis pathophysiology Physical examination Physiotherapy pregabalin radiological reduced reported required Research resolution of symptom routine Sinovac Socioeconomic Factors the patient triggers vaccination Vaccinations variant viral infection viral infections [DOI] 10.1097/MD.0000000000029333 PMC 바로가기 [Article Type] Review
Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors조합 AAV/RNAi 발현 벡터를 사용한 SARS-CoV-2의 생체외 및 생체내 억제Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] AAV acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adeno-associated virus Antiviral Antiviral agents antiviral RNAi Cell clinically cocktail complement coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease symptom effective escape mutant escape mutants experiment expression vector flexible Genetic global effort Gut hACE2 in vivo infected cell infected cells intestinal cells intranasal mice mutational escape. N gene N genes organoids pandemic prevented RdRP RNA RNAi SARS virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RdRp SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus suppressed the SARS-CoV-2 therapeutic translation triggers Vaccine vector vectors viral adaptation Viral load viral loads virus wild-type [DOI] 10.1016/j.ymthe.2022.01.024 PMC 바로가기 [Article Type] Article
Relapsed and newly diagnosed Graves’ disease due to immunization against COVID-19: A case series and review of the literature코로나19 예방접종으로 인한 그레이브스병 재발 및 새로 진단: 사례 시리즈 및 문헌 고찰Review Published on 2022-04-012022-09-11 Journal: Journal of autoimmunity [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adjuvant adjuvants age Autoimmune Autoimmune thyroid diseases case sery causal relationship coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine cross-reactivity develop diagnosed disease environmental factor environmental factors Factors female Genetic genetic factors grave Graves' disease Hashimoto Hashimoto's thyroiditis Hyperthyroidism immunization inactivated Inactivated COVID-19 vaccine Infection literature review mammalian protein manifestation mechanism mechanisms median median age molecular mRNA mRNA vaccine mRNA vaccine. multicenter one patient Patient Prospective Study reported SARS-CoV-2 severe acute respiratory syndrome Coronavirus similarity symptom onset the median the patient the vaccine thought Thyroid Thyroiditis Trigger triggers viral particle Viral particles virus [DOI] 10.1016/j.jaut.2022.102809 PMC 바로가기 [Article Type] Review
The (apparent) antibody paradox in COVID-19COVID-19의 (겉보기) 항체 역설Article Published on 2022-04-012022-09-11 Journal: Expert review of clinical immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibodies antibody Antibody Response Area benefit convalescent plasma COVID-19 defined Delayed dominance dominant elevated Evidence expert Host Humoral immunity Immunity Immunological response increasingly Infection inflammatory reaction lack magnitude monoclonal monoclonal antibodies observation Omicron variant Patient Protective protective mechanism protective role reaction SARS-CoV-2 severe COVID-19 severe disease syndrome T cell T cell response T cell responses T cells T-cell Response the antibody response therapeutic Trigger triggered triggers vaccination vaccination. Viral viral loads virus [DOI] 10.1080/1744666X.2022.2044797 PMC 바로가기 [Article Type] Article